Transient hemorrhagic diathesis associated with an inhibitor of prothrombin with lupus anticoagulant in a 1½-year-old girl: Report of a case and review of the literature

✍ Scribed by Lee, Margaret T.; Nardi, Michael A.; Hu, Grace; Hadzi-Nesic, Joan; Karpatkin, Margaret

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 676 KB
• Volume: 51
• Category: Article
• ISSN: 0361-8609
• DOI: 10.1002/(sici)1096-8652(199604)51:4<307::aid-ajh10>3.0.co;2-b

✦ Synopsis

Acquired inhibitors of coagulation causing bleeding manifestations are rare in children, particularly without an associated underlying disorder such as autoimmune disease. We describe an otherwise healthy lhyear-old girl who had extensive spontaneous bruising and prolonged bleeding from venipuncture sites. Prothrombin time (PT) and activated partial thrombopiastin time (APlT) were prolonged, with evidence of an immediate-acting inhibitor. Thrombin clotting time, fibrinogen, and platelets were normal. Biologic assay of factors II, V, Vii, and X were ail low, with increasing values at higher dilutions. However, by immunoassay and/or chromogenic assays, only factor ii was reduced. An antibody which failed to neutralize prothrombin activity in vitro was detected against radiolabeled prothrombln. Coagulation studies normalized in parallel with cilnicai recovery and disappearance of the antibody. This case demonstrates acute hypoprothrombinemia-lupus anticoagulant syndrome as a rare presentation of bleeding diathesis in a healthy young child. Q 1996 WiIey-Liss. Inc.