Transient engraftment of syngeneic bone marrow after conditioning with high-dose cyclophosphamide and thoracoabdominal irradiation in a patient with aplastic anemia
✍ Scribed by Dr. Kosei Matsue; Takeo Niki; Shintaro Shiobara; Mikio Ueda; Shigeki Ohtake; Takao Mori; Tamotsu Matsuda; Mine Harada
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 802 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0361-8609
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✦ Synopsis
We describe the clinical course of a 16 year old girl with aplastic anemia who was treated by syngeneic bone marrow transplantation. Engraftment was not obtained by simple infusion of bone marrow without immunosuppression. The patient received a high-dose cyclophosphamide and thoracoabdominal irradiation, followed by second marrow transplantation from the same donor. Incomplete but significant hematologic recovery was observed; however, marrow failure recurred 5 months after transplantation. Since donor and recipient pairs were genotypically identical, graft failure could not be attributed to immunological reactivity of recipient cells to donor non-HLA antigens. This case report implies that graft failure in some cases of aplastic anemia might be mediated by inhibitory cells resistant to cyclophosphamide and irradiation.