Huntington's disease (HD) is a neurodegenerative and hereditary disease characterized by progressive movement disorders and mental and behavioral abnormalities. The HD gene is an expanding and unstable trinucleotide repeat (CAG repeat sequences). We studied 77 individuals from 38 families with HD in
✦ LIBER ✦
Transglutaminase activity is related to CAG repeat length in patients with Huntington’s disease
✍ Scribed by L. Cariello; T. de Cristofaro; Laura Zanetti; Teresa Cuomo; Luigi Di Maio; Giuseppe Campanella; Silvana Rinaldi; Paolo Zanetti; Roberto Di Lauro; S. Varrone
- Publisher
- Springer
- Year
- 1996
- Tongue
- English
- Weight
- 145 KB
- Volume
- 98
- Category
- Article
- ISSN
- 0340-6717
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## BACKGROUND. The FHIT gene, located at human chromosome 3p14.2, frequently is deleted in a number of human tumors, including breast carcinoma. Its protein product (Fhit) is presumed to have tumor suppressor function. Loss of expression of a tumor suppressor gene is an important step in tumor prog