Transgenic mouse models of amyotrophic l
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Jean-Pierre Julien; Jasna Kriz
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Article
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2006
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Elsevier Science
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English
β 377 KB
The discovery of missense mutations in the gene coding for the Cu/Zn superoxide dismutase 1 (SOD1) in subsets of familial cases was rapidly followed by the generation of transgenic mice expressing various forms of SOD1 mutants. The mice overexpressing high levels of mutant SOD1 mRNAs do develop moto