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Transgenic mouse models for tumour-suppressor genes

✍ Scribed by T. R. KUMAR; L. A. DONEHOWER; A. BRADLEY; M. M. MATZUK

Book ID: 114742830
Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 509 KB
Volume: 238
Category: Article
ISSN: 0954-6820
DOI: 10.1111/j.1365-2796.1995.tb00928.x

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Two molecular pathways leading to cancer are known. Common-type cancers arise from the 'tumour suppressor' pathway, characterized by gross chromosomal changes and allelic losses (LOH) in an average of 25 per cent or more of randomly chosen chromosomal loci. The 'mutator pathway' has been recognized