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Transgenic mouse model for the fragile X syndrome

✍ Scribed by Kooy, R. Frank; D'Hooge, Rudi; Reyniers, Edwin; Bakker, Cathy E.; Nagels, Guy; De Boulle, Kristel; Storm, Katrien; Clincke, Gilbert; De Deyn, Peter P.; Oostra, Ben A.; Willems, Patrick J.

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 513 KB
Volume: 64
Category: Article
ISSN: 0148-7299
DOI: 10.1002/(sici)1096-8628(19960809)64:2<241::aid-ajmg1>3.0.co;2-x

No coin nor oath required. For personal study only.

✦ Synopsis

Transgenic fragile X knockout mice have been constructed to provide an animal model to study the physiologic function of the fragile X gene (FMR1) and to gain more insight into the clinical phenotype caused by the absence of the fragile X protein. Initial experiments suggested that the knockout mice show macroorchidism and cognitive and behavioral deficits, abnormalities comparable to those of human fragile X patients. In the present study, we have extended our experiments, and conclude that the Fmrl knockout mouse is a reliable transgenic model to study the fragile X syndrome.

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