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Transgenic mouse and cell culture models demonstrate a lack of mechanistic connection between endoplasmic reticulum stress and tau dysfunction

โœ Scribed by Anne S. Robinson; Michelle L. Spatara

Book ID
118466689
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
37 KB
Volume
6
Category
Article
ISSN
1552-5260

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Transgenic mouse and cell culture models
Transgenic mouse and cell culture models demonstrate a lack of mechanistic connection between endoplasmic reticulum stress and tau dysfunction
โœ M.L. Spatara; A.S. Robinson ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 949 KB

## Abstract In vivo aggregation of tau protein is a hallmark of many neurodegenerative disorders, including Alzheimer's disease (AD). Recent evidence has also demonstrated activation of the unfolded protein response (UPR), a cellular response to endoplasmic reticulum (ER) stress, in AD, although th