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Transgenic mice expressing human Alzheimer's β-amyloid precursor protein produce high amounts of β-peptide

✍ Scribed by Richter, Karl; Jürgens, Uwe


Book ID
124126722
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
200 KB
Volume
15
Category
Article
ISSN
0197-4580

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One of the pathological lesions in Alzheimer's disease (AD) is the amyloid or senile plaque. The plaque core is predominantly made up of amyloid beta peptide (AP), a 42-43 amino acid peptide derived from amyloid precursor protein (APP). APP is a membrane bound glycoprotein which is expressed ubiquit