Transgenic expression of the human Vitamin D receptor (hVDR) in the duodenum of VDR-null mice attenuates the age-dependent decline in calcium absorption

Vitamin D mediates its action in human c

Vitamin D mediates its action in human colon carcinoma cells in a calcium-sensing receptor-dependent manner: downregulates malignant cell behavior and the expression of thymidylate synthase and survivin and promotes cellular sensitivity to 5-FU

✍ Guangming Liu; Xin Hu; Subhas Chakrabarty 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 402 KB 👁 1 views

## Abstract Vitamin D (VD) protects against colon carcinogenesis by mechanisms not fully understood. We had earlier reported on the similarity in the biologic action of VD and that of the calcium‐sensing receptor (CaSR) in human colon carcinoma cells. At the molecular level, the CaSR gene contains