Novel gene technologies have allowed us to manipulate the genetic balance of candidate molecules in mice in a controllable manner. Homologous or site-speciยฎc recombination in embryonic stem cells allows us to study the consequences of deยฎciencies, mutations, and conditional or tissue-speciยฎc express
Transgenic animal models of cardiovascular disease
โ Scribed by Graham Barrett; John J. Mullins
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 498 KB
- Volume
- 3
- Category
- Article
- ISSN
- 0958-1669
No coin nor oath required. For personal study only.
โฆ Synopsis
Transgenic experimentation has become a crucial part of hypertension and atherosclerosis research, and is growing more important in several other areas of cardiovascular disease. It has recently made a particular contribution to understanding the role of the renin-angiotensin system in controlling hypertension. The study of blood pressure regulation, cardiac hypertrophy, atherogenesis and thrombosis are also benefiting from the transgenic approach.
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