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Transgenic and Knockout Mice in Research on Prion Diseases

✍ Scribed by Alex J. Raeber; Sebastian Brandner; Michael A. Klein; Yves Benninger; Christine Musahl; Rico Frigg; Christiane Roeckl; Michael B. Fischer; Charles Weissmann; Adriano Aguzzi

Book ID
111403904
Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
285 KB
Volume
8
Category
Article
ISSN
1015-6305

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## Abstract ## Objective: Transgenic (Tg) mice expressing chimeras of mouse and human prion proteins (PrPs) have shorter incubation periods for Creutzfeldt‐Jakob disease (CJD) prions than mice expressing full‐length human PrP. Increasing the sequence similarity of the chimeric PrP to mouse PrP, by