Transfusion-related acute lung injury following intravenous anti-D administration in an adolescent

✍ Scribed by Sivan Berger-Achituv; Martin H. Ellis; Brian R. Curtis; Baruch Wolach

• Publisher: John Wiley and Sons
• Year: 2008
• Tongue: English
• Weight: 95 KB
• Volume: 83
• Category: Article
• ISSN: 0361-8609
• DOI: 10.1002/ajh.21185

✦ Synopsis

Abstract

Transfusion‐related acute lung injury (TRALI) is associated with administration of all plasma containing blood products. We present a 14‐year‐old adolescent diagnosed with idiopathic thrombocytopenic purpura who developed acute respiratory insufficiency compatible with TRALI within 5 hr following intravenous anti‐D. Full blown noncardiogenic pulmonary edema was noted after 9 hr. Mechanical ventilation was not required and the patient made a full recovery after 36 hr. Analysis of the anti‐D preparation revealed reactivity against the neutrophil FcγRIIIb. A postinfusion serum sample contained antibodies against class I human HLA‐A11 antigen. Clinicians should consider TRALI in patients developing unexplained dyspnea after receiving intravenous anti‐D. Am. J. Hematol. 2008. © 2008 Wiley‐Liss, Inc.