Transfusion management of an IgA deficient patient with anti-IgA and incidental correction of IgA deficiency after allogeneic bone marrow transplantation

✍ Scribed by Rogers, R.L.; Javed, T.A.; Ross, R.E.; Virella, G.; Stuart, R.K.; Frei-Lahr, D.

• Book ID: 101215048
• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 28 KB
• Volume: 57
• Category: Article
• ISSN: 0361-8609
• DOI: 10.1002/(sici)1096-8652(199804)57:4<326::aid-ajh10>3.0.co;2-6

✦ Synopsis

A patient with multiple myeloma was noted to have an IgA deficiency during investigation of a possible transfusion reaction due to IgA deficiency and anti-IgA. Because of the patient's age, otherwise good health, and early stage of disease, he was enrolled in a research treatment protocol that involved an allogeneic bone marrow transplant (BMT). The BMT successfully put the patient in complete remission from his multiple myeloma and corrected his IgA deficiency. Class-specific IgG anti-IgA antibody that had been identified prior to BMT was no longer detectable in his plasma. Anaphylactic transfusion reactions were successfully avoided by using a combination of IgA-deficient and washed blood components including the marrow graft, and IgA-reduced intravenous immunoglobulin.