Current evidence suggest an important role for increased repair of drug-induced DNA damage as one of the major mechanisms involved in tumor cell resistance to cis-DDP. In this study, we examined the DNA repair capacity and the activities of three DNA repair related proteins, namely, DNA polymerases
✦ LIBER ✦
Transfusion independence and HMGA2 activation after gene therapy of human β-thalassaemia
✍ Scribed by Cavazzana-Calvo, Marina; Payen, Emmanuel; Negre, Olivier; Wang, Gary; Hehir, Kathleen; Fusil, Floriane; Down, Julian; Denaro, Maria; Brady, Troy; Westerman, Karen
- Book ID
- 109899121
- Publisher
- Nature Publishing Group
- Year
- 2010
- Tongue
- English
- Weight
- 485 KB
- Volume
- 467
- Category
- Article
- ISSN
- 0028-0836
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## Abstract We investigated the effects of overexpression of the tuberous sclerosis‐1 and ‐2 (__TSC1/2__) gene products (hamartin and tuberin, respectively) in the human kidney epithelial cell line 293 with an inducible expression system. As we had observed previously in fibroblasts, 293 cells over