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Transfusion-associated graft-versus-host disease in immunocompetent patient: Early diagnosis and therapy

✍ Scribed by Sakurai, Masahiro; Moizumi, Yoshimasa; Uchida, Shigeharu; Imai, Yoshimichi; Tabayashi, Koichi

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
27 KB
Volume
58
Category
Article
ISSN
0361-8609

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✦ Synopsis

We report a case of transfusion-associated graft-versus-host disease in a previously healthy, 68-year-old Japanese man following an emergency surgery for an acute aortic dissection. We confirmed the chimerism of lymphocytes and the effect of drug therapy using DNA polymorphism analysis. This method is a sensitive, convenient, and rapid method that it is also useful for the evaluation of therapy. And the combination therapy with methylprednisolone, cyclosporine, and 15-deoxyspergualin may be effective in treating transfusion-associated GVHD. Am.

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