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Transforming growth factor-β1 promotes lung adenocarcinoma invasion and metastasis by epithelial-to-mesenchymal transition

✍ Scribed by Hui-Jun Zhang; He-Yong Wang; Hong-Tao Zhang; Jin-Mei Su; Jun Zhu; Hai-Bing Wang; Wen-Yong Zhou; Hui Zhang; Ming-Chuan Zhao; Lei Zhang; Xiao-Feng Chen

Book ID: 106459579
Publisher: Springer
Year: 2011
Tongue: English
Weight: 397 KB
Volume: 355
Category: Article
ISSN: 0300-8177
DOI: 10.1007/s11010-011-0869-3

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## Abstract Constitutive activation of the MAP kinase kinase MEK1 induces oncogenic transformation in intestinal epithelial cells. Loss of cell–cell adhesion followed by the dissociation of epithelial structures is a prerequisite for increased cell motility and tumor invasion. This phenotypic switc