## BACKGROUND. Apoptosis is induced by various anticancer agents or radiation through the tumor suppressor gene p53-dependent pathway and is also induced by other factors, including transforming growth factor-PI (TGF-0,). In this study, the authors investigated whether TGF-0, would induce apoptosi
Transforming growth factor β1 is unlikely to mediate p53 abnormalities in breast cancer
✍ Scribed by Mr A. M. Thompson; C. M. Steel; U. Chetty; J. M. Dixon; D. C. Carter
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 196 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0007-1323
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Unlike normal intestinal cells, colorectal-carcinoma cell lines are usually not responsive to transforming growth factor PI. The cyclin-dependent kinase inhibitor p2 I that is induced by X irradiation in cells expressing normal pS3 can also be induced by TCF-P I by a p53-independent pathway. We have
## Abstract Tenascin‐C (TN‐C) and matrix metalloproteinases (MMPs) are highly expressed in cancer tissues and probably promote cell migration during cancer progression. TN‐C and MMPs are often co‐localized in areas of active tissue remodeling in pathologic conditions, suggesting reciprocal regulati
## Abstract Transforming growth factor‐β1 (TGF‐β1) is a crucial molecule for stimulation of breast cancer invasion and formation of bone metastases. The molecular mechanisms of how TGF‐β1 mediates these effects have yet to be completely determined. We have found that activating transcription factor
## Abstract ## Background. Transforming growth factor β (TGF‐β) is a pleiotropic cytokine that has diverse roles in cancer. Rate of production of the major isoform, TGF‐β1, is linked with rs1982073 single nucleotide polymorphism in __TGFB1__ gene signal sequence. ## Methods. Peripheral blood DNA
## Abstract The net balance between urokinase‐type plasminogen activator (uPA) and plasminogen activator inhibitor type‐1 (PAI‐1) has been implicated in tumor cell invasion and metastasis. To elucidate the mechanism of the transforming growth factor‐β1 (TGF‐β1)‐dependent up‐regulation of PAI‐1 expr