Transforming Growth Factor β1 Helps Maintain Differentiated Functions in Mitogen-Treated Primary Rat Hepatocyte Cultures
✍ Scribed by Helene Lilja; Yukio Kamohara; Toomas Neuman; Achilles A. Demetriou; Jacek Rozga
- Book ID
- 115637426
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 237 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1522-4724
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## ABSTRACT Transforming growth factor β1 (TGFβ1) elevated the phosphoenolpyruvate carboxykinase (PEPCK) mRNA abundance in primary cultures of rat hepatocytes. Although this increase was not as large as the rise in PEPCK gene expression induced by the cAMP‐elevating agents glucagon or isoproterenol
We have previously shown that transforming growth factor-b1 (TGF-b1) enhances the epidermal growth factor-(EGF) and transforming growth factor-a (TGF-a)stimulated motility of rat hepatocytes in an extracellular matrix (ECM)-dependent fashion (Stolz and Michalopoulos, 1997, J. Cell. Physiol., 170:57-