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Transforming growth factor-β1 enhances the interferon-γ-dependent, interleukin-12-independent pathway of T helper 1 cell differentiation

✍ Scribed by Ronald B. Smeltz; June Chen; Ethan M. Shevach

Book ID
108781641
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
406 KB
Volume
114
Category
Article
ISSN
0019-2805

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## T helper type 1 development of naive CD4+ T cells requires the coordinate action of interleukin42 and interferon-y and is inhibited by transforming growth factor+* Institut fur Immunologie, Maim It was observed in vitro and in vivo that both interferon (1FN)y and interleukin (1L)-12 can promote