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Transforming growth factor β1 down-regulates Runx-2 and alkaline phosphatase activity of human dental pulp cells via ALK5/Smad2/3 signaling

✍ Scribed by Po-Shuen Lin; Mei-Chi Chang; Chiu-Po Chan; Sheng-Yang Lee; Jang-Jaer Lee; Yi-Ling Tsai; Hui-Chun Tseng; Tseng-Fang Tai; Hsueh-Jen Lin; Jiiang-Huei Jeng

Book ID: 116943158
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 695 KB
Volume: 111
Category: Article
ISSN: 1528-395X
DOI: 10.1016/j.tripleo.2010.09.079

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## Abstract The net balance between urokinase‐type plasminogen activator (uPA) and plasminogen activator inhibitor type‐1 (PAI‐1) has been implicated in tumor cell invasion and metastasis. To elucidate the mechanism of the transforming growth factor‐β1 (TGF‐β1)‐dependent up‐regulation of PAI‐1 expr