Transforming Growth Factor-β1 and Regulators of Apoptosis : P53, Bax, and Bcl-xL in Colorectal Cancers
✍ Scribed by Stanislaw Sulkowski; Andrzej Wincewicz; Mariola Sulkowska; Mariusz Koda
- Book ID
- 111399169
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 236 KB
- Volume
- 1171
- Category
- Article
- ISSN
- 0890-6564
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The authors previously reported that transforming growth factor  1 (TGF- 1 ) induces apoptosis in McA-RH7777 (7777) and McA-RH8994 (8994) rat hepatoma cell lines. Although these cell lines exhibit different responses to glucocorticoid treatment in various cellular functions and gene expression, de
## BACKGROUND. Apoptosis is induced by various anticancer agents or radiation through the tumor suppressor gene p53-dependent pathway and is also induced by other factors, including transforming growth factor-PI (TGF-0,). In this study, the authors investigated whether TGF-0, would induce apoptosi