Transforming growth factor-β downregulates interleukin-2-induced phosphorylation of signal transducer and activator of transcription 5 in human renal cell carcinoma

Interleukin-1β and tetradecanoylphorbol

Interleukin-1β and tetradecanoylphorbol acetate-induced biosynthesis of tumor necrosis factor α in human hepatoma cells involves the transcription factors ATF2 and c-Jun and stress-activated protein kinases

✍ Inge Bauer; Jude Al Sarraj; Charles Vinson; Reinhard Larsen; Gerald Thiel 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 286 KB

## Abstract The proinflammatory cytokine tumor necrosis factor (TNF) α is mainly produced in cells from the monocyte/macrophage lineage. TNFα is also a key signaling molecule in the liver functioning as an important physiological and pathogenic mediator. In hepatocytes or human hepatoma cells TNFα