Transforming growth factor-β and γ-interferon have dual effects on growth of peripheral glia

✍ Scribed by P. A. Eccleston; K. R. Jessen; R. Mirsky

• Book ID: 102909551
• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 730 KB
• Volume: 24
• Category: Article
• ISSN: 0360-4012
• DOI: 10.1002/jnr.490240410

✦ Synopsis

The influence of transforming growth factor-p (TGF-P) and y-interferon on DNA synthesis in Schwann cells and enteric glia in culture has been studied. TGF-P stimulated the DNA synthesis of short-term (less than 2 weeks in culture) Schwann cells, whereas y-interferon was ineffective. The stimulatory effect of TGF-P was additive to the stimulation of DNA synthesis due to axonal membrane fragments. In contrast to their effect on short-term Schwann cells, both TGF-P and y-interferon inhibited DNA synthesis in enteric glial cells and in long-term (over 3 months in culture) Schwann cells. When short-term Schwann cells were stimulated to divide by axolemma or glial growth factor, y-interferon did not inhibit this enhanced DNA synthesis although it suppressed DNA synthesis induced by CAMP analogues. These results raise the possibility that TGF-P and y-interferon might have a role in controlling glial proliferation during development and/or regeneration of the peripheral nervous system.