Transforming Growth Factor-β and Hepatocyte Growth Factor Produced by Gastric Fibroblasts Stimulate the Invasiveness of Scirrhous Gastric Cancer Cells
✍ Scribed by Inoue, Tohru ;Chung, Yong-Suk ;Yashiro, Masakazu ;Nishimura, Shigehiko ;Hasuma, Tadayoshi ;Otani, Shuzo ;Sowa, Michio
- Book ID
- 108581391
- Publisher
- Wiley (Blackwell Publishing)
- Year
- 1997
- Tongue
- English
- Weight
- 478 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0910-5050
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## Abstract ## Background and Objectives Regulatory T cells (Treg) inhibits immune responses mediated by T cells. This study aimed to investigate whether Treg are accumulated in human gastric cancer tissue and the mechanism of Treg induction by gastric cancer cells. ## Methods Tissue infiltrated
Forty-three sporadic gastric cancers were analyzed with regard to whether mutations of simple repeated sequences in the transforming growth factor fi type II receptor ( T p -I / ) gene are associated with microsatellite instability (MSI) and gastric carcinogenesis. In 12 ofthe 43 cancers (28%), MSI