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Transforming growth factor β-1 positively modulates the bioactivity of fibroblast growth factor on corneal endothelial cells

✍ Scribed by Jean Plouët; Denis Gospodarowicz

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
839 KB
Volume
141
Category
Article
ISSN
0021-9541

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✦ Synopsis

Transforming growth factor beta-1 (TCFP-I), known as an inhibitor of vascular endothelial cell proliferation in vitro, stimulates bovine corneal endothelial cells (BCE) proliferation. It also positively modulates the response of BCE cells to fibroblast growth factor (FGF) and epidermal growth factor ( E L F ) . This effect is concentration dependent within a physiological range of TCFP-1, but it is blocked if cells are cultured on extracellular-matrix-coated dishes instead of plastic. TGFP-1 does not modify the number or the affinity of bFGF receptors on BCE cell surface but increases the bFGF content of these cells. This suggests that TGFP-1 might act through regulation of bFGF synthesis in BCE cells.

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