In vitro studies have shown hepatocyte growth factor (HGF) to be a potent mitogen for hepatocytes. Direct evidence of a mitogenic role in vivo was sought by inhibiting HGF activity, using continuous administration of neutralizing antibody to rats which had a stimulus for liver regeneration. Alzet os
Transforming Growth Factor α Levels in Liver and Blood Correlate Better than Hepatocyte Growth Factor with Hepatocyte Proliferation during Liver Regeneration
✍ Scribed by Tomoaki Tomiya; Itsuro Ogata; Kenji Fujiwara
- Book ID
- 117022816
- Publisher
- American Society for Investigative Pathology
- Year
- 1998
- Tongue
- English
- Weight
- 389 KB
- Volume
- 153
- Category
- Article
- ISSN
- 0002-9440
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After a partial hepatectomy, TGF-a mRNA has been shown of chronic liver disease; CH, chronic hepatitis; LC, liver cirrhosis; LI, labeling index; RTto increase in hepatocytes at the time of DNA synthesis con-PCR, reverse-transcriptase polymerase chain reaction; cDNA, complementary DNA.
Transforming growth factor-a and hepatocyte growth factor are important stimulators of hepatocyte proliferation. In this series of experiments we sought to measure the expression of transforming growth factor-a mRNA by hepatocytes in response to toxic liver injury produced by carbon tetrachloride or
Hepatocyte growth factor, a potent hepatocyte mitogen in vitro, appears to trigger hepatocyte regeneration after partial hepatectomy and after acute liver cell netcrosis. Transforming growth factor-a and transforming growth factor+, may also be involved in the control of liver regeneration. In this