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TRANSFORMING GROWTH FACTOR-BETA (TGF-β)-INDUCED ACTIVATION OF DNA METHYLTRANSFERASE (DNMT) IS ASSOCIATED WITH MORE ADVERSE TUMOR FEATURES

✍ Scribed by Zhang, Qiang; Jang, Thomas; Smith, Norm D; Javonovic, Borko; Zhu, Lihua J; Lee, Chung


Book ID
123580538
Publisher
Lippincott Williams and Wilkins
Year
2009
Tongue
English
Weight
49 KB
Volume
181
Category
Article
ISSN
0022-5347

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The epidermal growth factor (EGF) receptor mediates the effects of both EGF and transforming growth factor alpha (TGFalpha). Recent data suggested that EGF acts as a partial agonist/antagonist in hepatocytes, TGFalpha exerting a larger maximal stimulation of DNA synthesis than EGF. To further study