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Transforming growth factor-beta (TGF-beta) induces vascular endothelial growth factor (VEGF) and plasminogen activator inhibitor-1 (PAI-1) gene expression through Smad3 transcription factor

✍ Scribed by Yanna Cao; Courtney M. Townsend Jr; Tien Ko

Book ID
113676640
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
78 KB
Volume
201
Category
Article
ISSN
1072-7515

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## Abstract VEGF and TGF‐β1 induce angiogenesis but have opposing effects on endothelial cells. VEGF protects endothelial cells from apoptosis; TGF‐β1 induces apoptosis. We have previously shown that VEGF/VEGF receptor‐2 (VEGFR2) signaling mediates TGF‐β1 induction of apoptosis. This finding raised