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Transforming Activity of a Synthetic c-Ha-ras Gene Containing O6-Methylguanine in Codon 12

✍ Scribed by Kamiya, Hiroyuki ;Miura, Kazunobu ;Ohtomo, Noriko ;Nishimura, Susumu ;Ohtsuka, Eiko


Book ID
108579372
Publisher
Wiley (Blackwell Publishing)
Year
1991
Tongue
English
Weight
353 KB
Volume
82
Category
Article
ISSN
0910-5050

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## Abstract To assess the requirements for papilloma formation in transgenic mice that over express transforming growth facto‐α (TGF‐α) in the epidermis (HK1.TGFα), we tested the sensitivity of HK1 TGFα mice to tumor promotion with 12‐__O__‐tetradecanoylphorbol‐13‐acetate (TPA) and analyzed the res