Transformation of temperature-sensitive growth mutant of BHK21 cell line to wild-type phenotype with hamster and mouse DNA

Restoration of endogenous wild-type p53

Restoration of endogenous wild-type p53 activity in a glioblastoma cell line with intrinsic temperature-sensitive p53 induces growth arrest but not apoptosis

✍ Jun Ikeda; Mitsuhiro Tada; Nobuaki Ishii; Hideyuki Saya; Kazuhiko Tsuchiya; Kumi 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 434 KB

p53 protein is a transcription factor involved in multiple tumor-suppressor activities including cell cycle control and apoptosis. TP53 gene is frequently mutated in glioblastoma, suggesting the importance of inactivation of this gene product in gliomagenesis. Restoration of p53 function in glioblas