Transformation of schiff bases derived from alpha-naphthaldehyde. Synthesis, spectral data and biological activity of new-3-aryl-2-(α-naphtyl)-4-thiazolidinones and N-aryl-N-[1-(α-naphthyl)but-3-enyl]amines

✍ Scribed by Vladimir Kouznetsov; William Rodríguez; Elena Stashenko; Carmen Ochoa; Celeste Vega; Miriam Rolón; David Montero Pereira; José A. Escario; Alicia Gémez Barrio

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2004
• Tongue: English
• Weight: 58 KB
• Volume: 41
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570410624

✦ Synopsis

Abstract

New N‐aryl substituted 2‐(α‐naphthyl)‐4‐thiazolidinones were prepared by the cyclocondensation of α‐mercaptoacetic acid and corresponding N‐(α‐naphthyliden)anilines. The same starting materials were utilized to obtain a new series of N‐aryl‐N‐[1‐(α‐naphthyl)but‐3‐enyl]amines, which was synthesized through an addition of the Grignard reagent (allylmagnesium bromide) to the double bond CN of the aldimines. The antichagasic and trichomonacidal in vitro activity, as well as, the antifungal and cytotoxic properties of some of these compounds were evaluated.