Transformation of Nε-Z-l-Lysine to Z-l-Oxylysine Using L-Amino Acid Oxidase from Providencia alcalifaciens and l-2-Hydroxyisocaproate Dehydrogenase from Lactobacillus confusus

Transformation ofNε-CBZ-l-lysine to CBZ-

Transformation ofNε-CBZ-l-lysine to CBZ-l-oxylysine usingl-amino acid oxidase fromProvidencia alcalifaciensandl-2-hydroxy-isocaproate dehydrogenase fromLactobacillus confusus

✍ Ronald L. Hanson; Kenneth S. Bembenek; Ramesh N. Patel; Laszlo J. Szarka 📂 Article 📅 1992 🏛 Springer 🌐 English ⚖ 427 KB

Biotransformations were developed to oxidize N epsilon-carbobenzoxy(CBZ)-L-lysine and to reduce the product keto acid to L-CBZ-oxylysine. Lysyl oxidase (L-lysine: O2 oxidoreductase, EC 1.4.3.14) from Trichoderma viride was relatively specific for L-lysine and had very low activity with N epsilon-sub