Transformation of Azadiradione to Nimbocinol and 17β-Hydroxynimbocinol, and StructurePesticidal-Activity Relationship of Triterpenoids isolated from Azadirachta indica A. Juss. (Neem)
✍ Scribed by Bina S. Siddiqui; Munawwer Rasheed; Shaheen Faizi; Firdous; S. Tariq Ali; Rajput M. Tariq; Syed Naeem-ul-Hassan Naqvi
- Publisher
- John Wiley and Sons
- Year
- 2003
- Tongue
- German
- Weight
- 180 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
Abstract
During studies on the structurepesticidal‐activity relationship of Azadirachta indica constituents, azadiradione (1) was treated with methanolic K~2~CO~3~ to obtain 7‐deacetyl derivative nimbocinol (2). Unexpectedly, 17__β__‐hydroxynimbocinol (3), reported earlier as a natural product, was also formed. The structurepesticidal‐activity relationship of triterpenoids 1–16 against Anopheles stephensi Liston is described towards understanding the active functionalities responsible for the pesticidal activity of triterpenoids having apoeuphane(apotirucallane) and gedunin skeleta. The pesticidal activities of triterpenoids 2–8 are reported for the first time.