Transformation of 2,2-dioxoisothiazolo[5,4,3-d,e]quinolines to pyrrolo[4,3,2-d,e]quinolin-2(1H)-ones
✍ Scribed by Zbigniew Wróbel
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 64 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
The sulfonamide group in 1H-1-alkyl-8-X-2,2-dioxoisothiazolo [5,4,3-d,e]quinolines 2 undergoes substitution with cyanide anion giving after hydrolysis pyrrolo[4,3,2-d,e]quinolin-2(1H)-ones 3.
📜 SIMILAR VOLUMES
## Synthesis of 2H-Benzo(2,3-g)pyridazino(4,5-d,e)quinolin-3-one Derivatives. -Treatment of the benzo(g)quinolinequinones (I), (III), and (IV) with hydrazine affords the corresponding title compounds (II) and (V), whereas reaction of (Ih) with (VI) yields the hydrazone (VII). -
## Abstract magnified image 5‐Hydrazinoquinoline and 8‐hydrazinoquinoline were converted __via__ Fischer syntheses with 3‐methyl‐butan‐2‐one into pyrido‐indolenines 2,3,3‐trimethyl‐3__H__‐pyrrolo[2,3‐__f__]quinoline **7** and 2,3,3‐trimethyl‐3__H__‐pyrrolo[3,2‐__h__]quinoline **11**, respectively.