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Transformation affects superoxide dismutase activity

✍ Scribed by Dean P. Loven; Duane L. Guernsey; Larry W. Oberley

Publisher
John Wiley and Sons
Year
1984
Tongue
French
Weight
445 KB
Volume
33
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

A human, aging lung fibroblast cell strain manifested both copper‐zinc superoxide dismutase activity (CuZn‐SOD) and manganese‐containing superoxide dismutase activity (MnSOD), and these activities were found to be modulated by physiological concentrations of thyroid hormone. The immortal cell lines examined, whether normal or malignant, had no MnSOD activity. The immortal normal cell lines examined had CuZnSOD activity which was modulated by thyroid hormone, whereas the immortal malignant cell lines had CuZnSOD activity which was not affected, or not as strongly affected, by the presence of thyroid hormone.

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