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Transferrin receptor on endothelium of brain capillaries

✍ Scribed by Jefferies, Wilfred A.; Brandon, Malcolm R.; Hunt, Simon V.; Williams, Alan F.; Gatter, Kevin C.; Mason, David Y.

Book ID
109737135
Publisher
Nature Publishing Group
Year
1984
Tongue
English
Weight
294 KB
Volume
312
Category
Article
ISSN
0028-0836

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The perfusion of rat brain with '251-transferrin resulted in a receptor-mediated uptake of transferrin into the endothelium of the blood-brain barrier followed by its detection in the brain. During a pulsechase experiment, lZSI-transferrin accumulated in the endothelial cells during the pulse, with