## Abstract We have previously shown that a recombinant human leukocyte interferon (IFNโฮฑA)^5^ can mediate an increase in cell surface tumor antigen expression in human carcinoma cells but not normal cells (Greiner __et al__., 1984). Such a biological response modifier may prove useful in circumven
โฆ LIBER โฆ
Transfer of the IL-6 gene into a human colorectal carcinoma cell line and consequent enhancement of tumor antigen expression
โ Scribed by Kwong Y. Tsang; Syed V.S. Kashmiri; Chen F. Qi; Carol Nieroda; Benjamin Calvo; Rosaria De Filippi; John W. Greiner; F.J. Primus; Jeffrey Schlom
- Book ID
- 107908425
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 531 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0165-2478
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We have examined the anti-tumor effect in nude mice caused by human pancreatic cancer cells (AsPC-1) modified to secrete IL-2 or IL-4. Loss of tumorigenicity of cytokineproducing, but not wild-type, cells was observed despite their unaltered in vitro proliferation rates; and these anti-tumor effects