Transfer of pl4arf gene in drug-resistant human breast cancer MCF-7/Adr cells inhibits proliferation and reduces doxorubicin resistance

A shift from normal to high glucose leve

A shift from normal to high glucose levels stimulates cell proliferation in drug sensitive MCF-7 human breast cancer cells but not in multidrug resistant MCF-7/ADR cells which overproduce PKC-βII

✍ Mayumi Yamamoto; Niketa A. Patel; Jennifer Taggart; Rajagopalan Sridhar; Denise 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 651 KB

## Glucose concentration may be an important factor in breast cancer cell proliferation because the prevalence of breast cancer is high in diabetic patients. To determine the role of protein kinase C (PKC)-␤II in regulating MCF-7 cell proliferation at different glucose concentrations, the effects o