Transfer of IFNγ-depleted CD4+ T cells together with CD8+ T cells leads to rejection of murine kidney sarcoma in mice

Adoptive transfer of an anti-MART-127–35

Adoptive transfer of an anti-MART-127–35-specific CD8+ T cell clone leads to immunoselection of human melanoma antigen-loss variants in SCID mice

✍ Francesco Lozupone; Licia Rivoltini; Francesca Luciani; Massimo Venditti; Luana 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 491 KB

## Abstract The identification of appropriate mouse models could be useful in carefully evaluating the actual role of the __in vivo__ development of antigen‐loss variants during antigen‐specific vaccine therapy of human tumors. In this study we investigated the level of efficacy of a MART‐1/Melan‐A