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Transfer Mechanism of Ionic Drugs: Piroxicam as an agent facilitating proton transfer

✍ Scribed by Frédéric Reymond; Guillaume Steyaert; Alessandra Pagliara; Pierre-Alain Carrupt; Bernard Testa; Hubert Girault

Book ID: 102860996
Publisher: John Wiley and Sons
Year: 1996
Tongue: German
Weight: 1019 KB
Volume: 79
Category: Article
ISSN: 0018-019X
DOI: 10.1002/hlca.19960790616

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✦ Synopsis

Facilitated proton transfer may be of potential significance in pharmacokinetic and pharmacodynamic processes. Here, we show that the NSAID piroxicam and its N -and 0-methybated derivatives act as ionophores for proton transfer across the H,0/1 ,2-dichloroethane interface. Investigations by cyclic voltammetry showed that the proton transfer occurs by interfacial protonation of the ionophore. The dissociation constants of the three compounds in the organic phase were calculated by Muts~rdu's theory. With this particular transfer mechanism, the present study exemplifies how electrochemistry at a liquid/liquid interface can be applied to calculate the fundamental thermodynamic parameters related to the pharmacokinetic behavior of ionic drugs.

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Transfer Mechanism of Ionic Drugs: Piroxicam as an agent facilitating proton transfer

✦ Synopsis

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