Transfection of oral cancer cells mediated by transferrin-associated lipoplexes: Mechanisms of cell death induced by herpes simplex virus thymidine kinase/ganciclovir therapy
✍ Scribed by Sílvia S. Neves; Ana B. Sarmento-Ribeiro; Sérgio P. Simões; Maria C. Pedroso de Lima
- Book ID
- 116274318
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 570 KB
- Volume
- 1758
- Category
- Article
- ISSN
- 0005-2736
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Human non-small cell lung cancer (NSCLC) cells were transfected with recombinant prodrug herpes simplex virus type I thymidine kinase (HSV-tk) cDNA, and the selected clones underwent apoptosis in response to induction by antiviral ganciclovir (GCV). The efficiency of GCV-induced growth inhibition an