## Background: Gene therapy strategies for the treatment of vascular disease such as the prevention of post-angioplasty restenosis require efficient, non-toxic transfection of vascular cells. in vitro studies in these cells contribute to vector development for in vivo use and for the evaluation of
Transfection of neonatal rat cochlear cells in vitro with an adenovirus vector
β Scribed by S Dazert; A Battaglia; A.F Ryan
- Book ID
- 117563788
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 556 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0736-5748
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## Abstract ## Introduction Internalization of wildβtype adenovirus is dependent on binding to a coxsackieβadenovirus receptor (CAR). Unfortunately, many tumors lack these receptors. We hypothesized that a novel RGD adenovirus, which binds by way of cellular integrins, would improve the transfecti