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Transfection of melanoma cells using DNA-polylsine complexes: Factors affecting complexation and gene transfer

✍ Scribed by Paul Lucas; David A. Milroy; Graham Smith; Aima N. Uduehi; Stephen H. Moss; Colin W. Pouton

Book ID
117628986
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
162 KB
Volume
4
Category
Article
ISSN
0928-0987

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## Abstract ## Background p53 is frequently mutated in many cancers including human head and neck squamous cell carcinoma and pancreatic cancer. In tumor models, wild‐type (wt) p53 gene transfer induces apoptosis and tumor regression __in vivo__, justifying the extensive clinical investigation of