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Transfected trophoblast-derived human cells can express a single HLA class I allelic product

✍ Scribed by José Boucraut; Razqallah Hakem; Anisia Gauthier; Reneé Fauchet; Philippe Le Bouteiller


Book ID
115096092
Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
556 KB
Volume
37
Category
Article
ISSN
0001-2815

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A new HLA-class-I altered phenotype is described in melanoma. This phenotype is the result of a combination of HLA-B-locus down-regulation and HLA-haplotype loss. The alteration was found in 2 melanoma cell lines generated from 2 patients; one was derived from an in vivo lesion (FM37) and the other