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Transduction of the IL-21 and IL-23 genes in human pancreatic carcinoma cells produces natural killer cell-dependent and -independent antitumor effects

โœ Scribed by Ugai, Shin-ichi; Shimozato, Osamu; Yu, Ling; Wang, Yan-Qing; Kawamura, Kiyoko; Yamamoto, Hiroshi; Yamaguchi, Taketo; Saisho, Hiromitsu; Sakiyama, Shigeru; Tagawa, Masatoshi


Book ID
110019038
Publisher
Nature Publishing Group
Year
2003
Tongue
English
Weight
289 KB
Volume
10
Category
Article
ISSN
0929-1903

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โœ Masaki Kimura; Yu Yoshida; Mitsuro Narita; Keizo Takenaga; Toshinao Takenouchi; ๐Ÿ“‚ Article ๐Ÿ“… 1999 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 330 KB ๐Ÿ‘ 2 views

We have examined the anti-tumor effect in nude mice caused by human pancreatic cancer cells (AsPC-1) modified to secrete IL-2 or IL-4. Loss of tumorigenicity of cytokineproducing, but not wild-type, cells was observed despite their unaltered in vitro proliferation rates; and these anti-tumor effects