Transduction of Human PBMC-Derived Dendritic Cells and Macrophages by an HIV-1-Based Lentiviral Vector System
β Scribed by Schroers, R
- Book ID
- 120406743
- Publisher
- Nature Publishing Group
- Year
- 2000
- Tongue
- English
- Weight
- 309 KB
- Volume
- 1
- Category
- Article
- ISSN
- 1525-0016
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Background Human monocytes play an important role in mediating human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system (CNS), and monocytes-derived macrophages (MDM) represent a major viral reservoir within the brain and other target organs. Current gene transduction of M
## Abstract ## Background Lentiviral gene transfer into hematopoietic cells has been mostly optimized with vectors carrying a single reporter gene. For many clinical applications, lentiviral vectors should contain more than one gene because transduced cells should be enriched by a selectable marke