Transduction and expression of the MDR gene in CD34+ cells from marrow and peripheral blood
β Scribed by C. Hesdorffer; A. Bank
- Publisher
- Springer
- Year
- 1996
- Tongue
- English
- Weight
- 87 KB
- Volume
- 38
- Category
- Article
- ISSN
- 1269-3286
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract ## Background Conventional geneβtherapy applications of hematopoietic stem cells (HSCs) involve purification of CD34+ progenitor cells from the mobilized peripheral blood, __ex vivo__ transduction of the gene of interest into them, and reinfusion of the transduced CD34+ progenitor cell
Retroviral-mediated gene transfer into hematopoietic stem cells provides the only means of stable transduction of these cells and their progeny for use with a variety of potentially therapeutic genes. Expression of the Moloney amphotropic retroviral receptor-pit-2 or GLVR-2-is critical to the recogn
## Abstract ## BACKGROUND Small cell lung carcinoma (SCLC) has the propensity to grow rapidly and metastasize extensively. Detection of microβdissemination of SCLC may have clinical relevance. For its detection, tumorβspecific gene expressions were examined in peripheral blood and bone marrow aspi