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Transducin and the inhibitory nucleotide regulatory protein inhibit the stimulatory nucleotide regulatory protein mediated stimulation of adenylate cyclase in phospholipid vesicle systems

โœ Scribed by Cerione, Richard A.; Codina, Juan; Kilpatrick, Brian F.; Staniszewski, Claudia; Gierschik, Peter; Somers, Robert L.; Spiegel, Allen M.; Birnbaumer, Lutz; Caron, Marc G.; Lefkowitz, Robert J.


Book ID
127215592
Publisher
American Chemical Society
Year
1985
Tongue
English
Weight
697 KB
Volume
24
Category
Article
ISSN
0006-2960

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In view of controversial findings regarding the mechanism for the increased intracellular hepatic cyclic 3':5' adenosine monophosphate levels in diabetic rats, we studied the dose-response relationship of the adenylate cyclase to glucagon stimulation in severely diabetic and in diabetic, insulin-tre