Transdifferentiation of Rat Hepatic Stellate Cells Results in Leptin Expression
β Scribed by James J. Potter; Lawrence Womack; Esteban Mezey; Frank A. Anania
- Book ID
- 115581551
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 530 KB
- Volume
- 244
- Category
- Article
- ISSN
- 0006-291X
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## Abstract Leptin is a 16βkDa hormone with an array of biologic actions. We, and others, have demonstrated that leptin is critical to the development of liver fibrogenesis both in vitro and in the lean littermates of __ob__/__ob__ mice exposed to carbon tetrachloride (CCl~4~). Controversy exists a
Transforming growth factor (TGF)-beta is critically involved in the activation of hepatic stellate cells (HSCs) that occurs during the process of liver damage, for example, by alcohol, hepatotoxic viruses, or aflatoxins. Overexpression of the TGF-beta antagonist Smad7 inhibits transdifferentiation a