Transdifferentiation molecular pathways of neonatal pig pancreatic duct cells into endocrine cell phenotypes

Exendin-4 differentiation of a human pan

Exendin-4 differentiation of a human pancreatic duct cell line into endocrine cells: Involvement of PDX-1 and HNF3β transcription factors

✍ Jie Zhou; Marco A. Pineyro; Xiaolin Wang; Maire E. Doyle; Josephine M. Egan 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 568 KB

## Abstract Exendin‐4 (EX‐4), a long acting agonist of GLP‐1, induces an endocrine phenotype in Capan‐1 cells. Under culture conditions which include serum, ∼10% of the cells contain insulin and glucagon. When exposed to EX‐4 (0.1 nM, up to 5 days), the number of cells containing insulin and glucag